Cancer

Our laboratory has been extensively investigating the molecular mechanisms underlying the resistance to conventional chemotherapy in ovarian cancer, which we believe it is an essential step forward toward development of effective therapeutic strategies for this deadly disease.

We have previously demonstrated that DNA damage response and repair machinery are severely attenuated in chemo-resistant ovarian cancer cells, along with a significantly compromised non-homologous end-joining DNA repair activity. In particular, we are interested in identifying novel therapeutic strategies to restore the attenuated DNA damage response and repair activity in order to overcome the chemotherapeutic drug resistance and increase the efficacy of cancer treatment.  
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‌‌- DNA Damage Response & DNA Repair