Endometrial Regeneration

Our laboratory has been working to develop novel therapeutic strategies to reactivate and regenerate the endometrial functionalis in patients suffering from repeated implantation failure owing to Asherman’s syndrome and thin endometrium. To study endometrial regeneration, we have developed 3D endometrial organoids, which exhibit phenotypical and functional similarities to their tissue of origin.  


Using these organoid-based 3D culture systems, our goals are to define the cellular and molecular mechanisms underlying the remarkable regenerative capacity of this dynamic organ, to harness its regenerative mechanisms for the precise repair of old or damaged tissues, and to understand how endometrial organoids can be used as a therapeutic intervention to improve the rates of embryo implantation and pregnancy.
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‌- Endometrial Organoid